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Why Iron, Folate, and B12 Are Critical for Healthy Blood During Pregnancy

September 24, 2025

Along with a woman's overall health, maintaining good blood health is essential during pregnancy. Adequate blood flow and a healthy blood supply are necessary for the baby's development. Blood is made up of different components, each playing a key role in maintaining overall health. Do you know why your gynaecologist insists on iron, folic acid, and Vitamin B12 during pregnancy? Read on to see why they are essential and how they influence your blood quality.

Blood Health During Pregnancy

During pregnancy, the volume of blood circulating in the body increases to support the growth and development of the fetus. Dilution happens when the blood volume increases, without a corresponding rise in other essential blood components. When the iron and folate levels do not increase correspondingly, it will lead to anaemia due to the deficiency.

Regular prenatal check-ups, supplements, and an improvement in diet can help improve the quantity and quality of blood during pregnancy. In case of complications or concerns, the doctor will prescribe medications, supplements, or even injections to minimise the negative impacts on both mother and baby.

Key Blood Factors in Pregnancy

Here are some factors of blood, necessary for blood health during pregnancy –

Haemoglobin – Haemoglobin is the protein component responsible for supplying oxygen through blood to all parts of the body. A deficiency of iron, folate, or vitamin B12 can decrease haemoglobin levels, resulting in anaemia. Reduced blood flow to the placenta can result in IUGR or preterm delivery.

Blood Clotting Factors – Blood clotting factors naturally increase in pregnancy to help prevent excessive bleeding during and after childbirth. However, too much increase can raise the risk of blood clots (DVT) in the legs, which may travel to vital organs and cause serious complications.

Rh Factor – Rh refers to the blood type. If the mother has a positive blood type and the baby has a negative blood type, an Rh immunoglobulin injection is given to the mother to prevent complications.

Iron

Iron is an essential nutrient that helps transport oxygen in the blood, supports brain development, and aids in immune function. Iron deficiency during pregnancy can cause fatigue, preeclampsia, preterm delivery, postpartum hemorrhage, or low birthweight.

Importance of Iron in Pregnancy

Iron plays a key role in a healthy pregnancy in the following ways –

Transport Oxygen – Iron helps in the formation of haemoglobin, the protein in the blood responsible for carrying oxygen. Without enough oxygen, the baby may not receive the oxygen and vital nutrients needed for healthy development.

Support Increasing Needs – During pregnancy, the demand on the mother's body increases. Iron supports the baby's growth and helps the mother make more blood to meet the higher needs.

Prevent Anaemia – Anaemia is a serious complication caused by insufficient red blood cells to carry oxygen.

Folate

Folate is an essential nutrient in early pregnancy. Many doctors prescribe folic acid supplements when women start trying to conceive or soon after they confirm pregnancy. Even if the woman is not suffering from any apparent folate or iron deficiency, this supplement ensures that the demands of pregnancy are met.

Importance of Folate in Pregnancy

Folate plays a vital role in pregnancy, especially in the early stages of fetal development.

Prevents Neural Tube Defects – Folate helps prevent anencephaly (a birth defect that prevents the brain, skull, and scalp from forming fully) and spina bifida (a birth defect that prevents the brain and spine from closing fully).

DNA Synthesis – Folate aids in cell division and in the synthesis of DNA and RNA, which are crucial for the baby's development.

Reduces Risks Associated with Pregnancy – It helps in reducing other pregnancy-related risks like low birth weight, preterm delivery, and other complications.

Red Blood Cells – Folate is an essential component in the development of healthy red blood cells, which in turn facilitates oxygen supply to the placenta.

B12

Vitamin B12 is derived mainly from animal-based foods, since it is made by microorganisms and stored in animals. So, it is common for vegetarians to have a B12 deficiency. Vitamin B12 deficiency can triple the risk of neural tube defects in the baby during pregnancy.

Need for Vitamin B12 in Pregnancy

Vitamin B12 is essential for blood health during pregnancy for the following reasons –

Nerve and Brain DevelopmentVitamin B12 is essential for the healthy development of the baby's brain and central nervous system.

Cell Formation - Vitamin B12 aids in the production of healthy red blood cells in the baby. It also supports the healthy development of the placenta and the baby's organs.

Prevent Neural Tube Defects – Vitamin B12 works along with folate to prevent neural tube defects like Spina bifida.

DNA Synthesis – Vitamin B12 plays a key role in synthesising DNA and cell division. These are critical for the baby's development.

Metabolism – Hormonal changes during pregnancy affect how the body's metabolism works. Sufficient Vitamin B12 intake helps in the metabolism of fats and proteins to provide the expecting mother with the required energy during pregnancy.

Book an online appointment with Dr. Shandhya Bhardwaj for Pregnancy & Gynecology related issues.

Sources of Iron, Folate, and B12

Pregnancy cravings and food aversions can make it challenging to meet the increasing demands for iron, folate, and B12. Here are some sources you can get these essential nutrients from –

Beef, liver, poultry, and eggs are rich in iron, folate, and B12.

Leafy green vegetables, legumes, and dairy products are rich vegetarian sources of folate and B12.

Citrus fruits, avocados, nuts, seeds, and whole grains are good sources of folate.

Increasing vitamin C food sources can help in the better absorption of iron.

Since B12 is not readily available in vegetarian foods, B12 fortified foods and nutritional yeast can help meet the body’s needs.

Conclusion

Iron, folate, and Vitamin B12 are essential nutrients that play a vital role in a safe pregnancy and healthy fetal development. To avoid deficiencies of these nutrients, many doctors prescribe supplements even before conception, right from the time the couple starts planning for pregnancy. These are among the first supplements prescribed upon confirmation of pregnancy to ensure proper fetal development.

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